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How do genes skip generations?

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How do genes skip generations? Empty How do genes skip generations?

Post Neon Knight Fri 27 Aug - 22:08

https://relevantgenetics.com/how-do-genes-skip-generations/  Selected quoting (slightly edited):

Genes are complicated. They don’t act in a vacuum. They interact with other genes, your environment, and a whole host of things we don’t fully understand yet. While there are some pretty cut and dry scenarios, a lot of things in genetics are a lot more nuanced. Here’s a few scenarios that may give the illusion of generation skipping.

Reduced Penetrance
Sometimes a gene by itself isn’t “strong” enough to cause an effect 100% of the time. Two people could have the exact same genetic mutation, but one might show no sign of it, while the other might be born with a cleft lip because of it. We call that “reduced penetrance,” or “incomplete penetrance.” In these kind of cases, grandpa, dad and the baby all have the same gene, but dad’s one of the lucky few that isn’t affected by it for some reason.

Variable Expressivity
Some genetic diseases have a long list of features they can cause, and most people with the condition will only have a fraction of the possible symptoms. Some of these symptoms are obvious medical conditions, but others might be more subtle, like the color of your eyes or how tall you are. You could have a group of relatives that all have the same gene, but some are severely affected by it and others end up having only a couple of subtle effects, and therefore go undiagnosed. We call this “variable expressivity” because the way the gene expresses itself varies from person to person.

X-Linked Disorders
When it comes to chromosomes, women have two X’s and men have an X and a Y (usually). If you look at a photo of these chromosomes, X looks like a giant next to Y. In other words, Y’s inventory is pretty lackluster compared to X’s. If women have a problem in a gene on their X chromosome, the other X can usually handle it on its own. But in a man, if his X chromosome has a problem, it’s got no back-up: just that little Y chromosome. So if you and your grandpa are red-green colorblind, that means your mom has to have the gene, too. She’s what we call a “silent carrier,” since her one working X-chromosome is enough to keep her seeing Christmas colors. No “skipping” has really taken place.




How do genes skip generations? Englan11

Between the velvet lies, there's a truth that's hard as steel
The vision never dies, life's a never ending wheel
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Post de Burgh Sun 6 Feb - 20:16

Genetics is simply an advanced version of Mendelian genetics; polygenicism.




'The most merciful thing in the world, I think, is the inability of the human mind to correlate all its contents. We live on a placid island of ignorance in the midst of black seas of infinity, and it was not meant that we should voyage far. The sciences, each straining in its own direction, have hitherto harmed us little; but some day the piercing together of dissociated knowledge will open up such terrifying vistas of reality, and of our frightful position therein, that we shall either go mad from the revelation or flee from the light into the peace and safety of a new dark age. [...]'
˜ H.P. Lovecraft
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